Though hippocampal volume reduction is a pathological hallmark of schizophrenia, the molecular pathway responsible for this degeneration remains unknown. Recent reports have suggested the potential role of impaired blood-brain barrier function in schizophrenia pathogenesis. However, direct evidence demonstrating an impaired BBB function is missing. In this preliminary study, we used immunohistochemistry and serum immunoglobulin G antibodies to investigate the state of BBB function in formalin-fixed postmortem samples from the hippocampus and surrounding temporal cortex of patients with schizophrenia and controls without (...) schizophrenia matched for age, sex, and race. Since a functional BBB prevents the extravasation of IgGs, detection of IgGs in the parenchyma is used as direct evidence of BBB breakdown. We also developed a semi-quantitative approach to quantify the extent of IgG leak and therein BBB breach. Analysis of our immunohistochemistry data demonstrated a significantly higher incidence of IgG leak in patients with schizophrenia compared to controls. Further, BBB permeability was significantly higher in advanced-age patients with schizophrenia than both advanced-age controls and middle-aged patients with schizophrenia. Male patients with schizophrenia also demonstrated a significant increase in IgG permeability compared to control males. Interestingly, the extravasated IgGs also demonstrated selective immunoreactivity for neurons. Based on these observations, we suggest that BBB dysfunction and IgG autoantibodies could be two key missing pathoetiological links underwriting schizophrenia hippocampal damage. (shrink)

In this paper we introduce a formalism for single-agent decision making that is based on Dynamic Argumentation Frameworks. The formalism can be used to justify a choice, which is based on the current situation the agent is involved. Taking advantage of the inference mechanism of the argumentation formalism, it is possible to consider preference relations, and conflicts among the available alternatives for that reasoning. With this formalization, given a particular set of evidence, the justified conclusions supported by warranted arguments will (...) be used by the agent’s decision rules to determine which alternatives will be selected. We also present an algorithm that implements a choice function based on our formalization. Finally, we complete our presentation by introducing formal results that relate the proposed framework with approaches of classical decision theory. (shrink)

Gil R, Arroyo-Anllo EM, Ingrand P, Gil M, Neau JP, Ornon C, Bonnaud V. Self-consciousness and Alzheimer’s disease. Acta Neurol Scand 2001: 104: 296–300. # Munksgaard 2001. Objectives – To propose a neuropsychological study of the various aspects of self-consciousness (SC) in Alzheimer’s disease. Methods – Forty-five patients with probable mild or moderate AD were included in the study. Severity of their dementia was assessed by the Mini Mental State (MMS). Fourteen questions were prepared to evaluate SC. Results – (...) No significant correlations were found between SC score and educational level, age, and duration of disease. A significant correlation was found between SC score and the severity of dementia, whereas frontal disturbances were just short of the significance threshold. The various aspects of SC were not impaired to the same degree. The most disturbed ones were awareness of cognitive deficiencies, moral judgements and prospective memory. The least disturbed aspects were awareness of identity and of mental representation of the body. Items relating to anosognosia and moral judgements were significantly correlated with the MMS score, whereas affective state, body representation disorders, prospective memory, and capacities for introspection were not related to the severity of the dementia. Consciousness of identity was sound, regardless of MMS score. Conclusions – AD clearly induces an heterogeneous impairment of SC. SC requires a convergence of many neural networks. In AD, neuronal alterations involve many cortical areas and information sent to the associative frontal cortex from memory, language and visuospatial areas is lacking or disturbed. Thus, the sequential order of successive stimuli cannot be maintained by the heteromodal associative cortex (dorsal convexity of the prefrontal cortex), and the supramodal associative cortex (located rostrally in the frontal lobes) is unable to provide reliable monitoring and assessment of simultaneous neural cognitive networks carrying insufficient and inadequate input. The core deficiency in AD patients might be impaired SC equated with the disability to maintain sequential and simultaneous ‘‘attention to life’’. The Self-Consciousness Questionnaire, a clinical scale providing multidimensional measurement, indicates that different aspects of consciousness are not correlated with overall cognitive deficiency as determined by the MMSE. (shrink)

While many may see the board game “Monopoly” as nothing more than a means of entertainment, it carries with it the potential to be used as an instrument for teaching ethical principles of business. This article makes a case that Monopoly be used to teach business ethics by providing the opportunity for a rich discussion regarding the dangers of concentrated wealth, collusion, and having an end goal that forces you into bankrupting your opponents and becoming the most cutthroat capitalist on (...) the board. Victory is achieved only by the self-serving actions of the individual; attempts at prosperity, generosity, and unity serve only to place the ethically minded player at a disadvantage. The article first provides an overview of the business principles on which Monopoly is based, and then discusses the disconnects between business ethics and winning at Monopoly, and how these disconnects can be used as a teaching tool. (shrink)

We discuss some methodological aspects of the relation between physics and metaphysics by dealing specifically with the case of non-relativistic quantum mechanics. Our main claim is that current attempts to productively integrate quantum mechanics and metaphysics are best seen as approaches of what should be called ‘the metaphysics of science’, which is developed by applying already existing metaphysical concepts to scientific theories. We argue that, in this perspective, metaphysics must be understood as an autonomous discipline. It results that this metaphysics (...) cannot hope to derive any kind of justification from science. Thus, one of the main motivations of such project, which is the obtaining of a scientifically respectable justification for the attribution of a single true metaphysical profile to the posits of a scientific theory, is doomed because of the emergence of metaphysical underdetermination from the outset. If metaphysics floats free from physics, which is a premise of such project of integration between these two areas, then it is always possible to attribute more than one metaphysical profile to dress physical entities. (shrink)

Information can be public among a group. Whether or not information is public matters, for example, for accounts of interdependent rational choice, of communication, and of joint intention. A standard analysis of public information identifies it with (some variant of) common belief. The latter notion is stipulatively defined as an infinite conjunction: for p to be commonly believed is for it to believed by all members of a group, for all members to believe that all members believe it, and so (...) forth. This analysis is often presupposed without much argument in philosophy. Theoretical entrenchment or intuitions about cases might give some traction on the question, but give little insight about why the identification holds, if it does. The strategy of this paper is to characterize a practical-normative role for information being public, and show that the only things that play that role are (variants of) common belief as stipulatively characterized. In more detail: a functional role for “taking a proposition for granted” in non-isolated decision making is characterized. I then present some minimal conditions under which such an attitude is correctly held. The key assumption links this attitude to beliefs about what is public. From minimal a priori principles, we can argue that a proposition being public among a group entails common commitment to believe among that group. Later sections explore partial converses to this result, the factivity of publicity and publicity from the perspective of outsiders to the group, and objections to the aprioricity of the result deriving from a posteriori existential presuppositions. (shrink)

The idea of family in the western culture has evolved throughout the centuries, from a strong-tied relationship between man-woman-children to the most varied combinations of person-to-person bonds. In many Western societies, the parents’ sexual orientation no longer defines the family structure. This paper studies identity and family relations by means of semiotics and conceptual metaphor theory.

Scholars in the humanities and social sciences have turned to ethics to theorize politics in what seems to be an increasingly depoliticized age. Yet the move toward ethics has obscured the ongoing value of political responsibility and the vibrant life it represents as an effective response to power. Sounding the alarm for those who care about robust forms of civic engagement, this book fights for a new conception of political responsibility that meets the challenges of today's democratic practice. Antonio Y. (...) Vázquez-Arroyo forcefully argues against the notion that modern predicaments of power can only be addressed ethically or philosophically through pristine concepts that operate outside of the political realm. By returning to the political, the individual is reintroduced to the binding principles of participatory democracy and the burdens of acting and thinking as a member of a collective. Vázquez-Arroyo historicizes the ethical turn to better understand its ascendence and reworks Adorno's dialectic of responsibility to reassert the political in contemporary thought and theory. (shrink)

Se van mostrar algunos contrastes en los lugares de la noción de mismidad del Poema de Parménides de Elea entre diversos textos de Martin Heidegger, con especial atención a qué tiene que ver el olvido de la «palabra enigma» de Parménides en Sein und Zeit con la noción de Sí mismo que allí se elabora. A través del camino hacia los “pensadores del inicio”, distinguir el horizonte de cuestionamiento del diálogo de Platón de aquel del Poema de Parménides, nos llevará (...) a su vez a señalar los diversos sentidos en que Heidegger piensa lo mismo en el Poema de Parménides. (shrink)

In ontological terms, what can we learn from the current state of the art in Epidemiology? Applying the Quinean criterion of ontological commitment, we can learn that there are several fundamental entities for the theory to work. One is a virus type entity, in which the (in)famous Coronavirus is a particular case. In metaphysical terms, this entity can, in principle, be understood in several ways. One of those ways, apparently, and perhaps intuitively, is the notion of object. Applying the metametaphysical (...) method of Unavailable Metaphysical Stories, we found that Epidemiology is incompatible with an object metaphysics. (shrink)

El propósito central de este artículo consiste en realizar una exploración crítica de la idea de educación democrática. La tesis que se defiende afirma que existe una relación de complementariedad entre los modelos deliberativo y agonista de la democracia, defendidos por Amy Gutmann y Chantal Mouffe, que permite una comprensión de la educación que satisface las exigencias morales que deben integrar una concepción democrática de ciudadanía. El texto inicia con un planteamiento acerca de la relación entre política y educación; seguidamente, (...) se exponen los enfoques agonal y deliberativo de la política en la interpretación de la democracia, para finalmente identificar los puntos de intersección entre ambos modelos y proponer algunas líneas de reflexión en torno a la comprensión la ciudadanía y la praxis de la formación ciudadana. (shrink)

Los estudios clásicos sobre el humor identifican una interrelación estrecha entre humor y angustia. En la serie narrativa Papelucho, esta interacción es constante en la trama de las distintas novelas. Este trabajo describe la interacción entre humor y angustia que se da en la obra y reflexiona sobre su sentido. Se concluye que la serie propone el humor como estrategia para enfrentar los hechos angustiantes ineludibles en la vida.

BARRICADAS ENTRE LOS ESTANTES - Posturas anarquistas dentro de la bibliotecología.

The aim of the study was to analyze the psychometric properties of the Social Justice Scale, composed by Representation, Recognition, and Redistribution dimensions. Likewise, the contribution of social dominance and the belief in a just world in each dimension were analyzed. A total of 471 young adults residing in Madrid participated in the online preliminary study, with an age range of 18–42 years with different genders. The main results indicated adequate psychometric properties for Social Justice Scale through its three dimensions. (...) In addition, we observed that both social dominance and belief in a just world might be psychosocial variables that modulate the levels of social justice. The main findings of the research and need for replication in future studies are discussed. (shrink)

We articulate a distinction between ontology, understood as involving existence questions, and metaphysics, understood as either providing for metaphysical profiles of entities or else as dealing with fundamentality and/or grounding and dependence questions. The distinction, we argue, allows a better understanding of the roles of metaontology and metametaphysics when it comes to discussing the relations between ontology and science on the one hand, and metaphysics and science on the other. We argue that while ontology, as understood in this paper, may (...) have reasonable perspectives for naturalization, given its relation to science, the same cannot be said for metaphysics, given that it is typically understood as an additional theoretical layer over science, not participating in the scientific investigation. That may result either in skepticism over metaphysics, or else on accepting that metaphysics is an autonomous branch of investigation, depending on one’s concern for metaphysics. (shrink)

This essay conceptualizes the intersections between contemporary catastrophes and political life by exploring how narratives of catastrophe mediate discursive and objective processes of catastrophization. It argues for the need to counteract catastrophization, a discursive and objective political phenomenon, by not only re-cognizing how catastrophes impinge on political life but by offering a more critical understanding of this intersection. The essay thus calls for the politicization of catastrophe as a response to the “catastrophization of political life.” Apropos of these concerns, it (...) engages with Habermas in order to explore how his political theory and interventions illustrate important aspects of the intersections between narratives of catastrophe and contemporary political life, say, how discursive catastrophization leads to the misrecognition of objective modalities of catastrophe. Overall, this essay offers an account of how to conceptualize catastrophe and catastrophization in order to articulate the broad contours of a political theory of catastrophe. (shrink)

Eduardo Arroyo, Armelle Auris, François Boissonnet, Paul HENRY, Pierre-Jean LABARRIERE, MATIEU, Gilles AILLAUD, Gérad THALMANN, Nicole MATHIEU, Jacques VIMARD, Michel QUAREZ, Leonardo CREMONINI, L'atelier d'Eduardo Arryo: Le carré blanc du ring, Rue Descartes, No. 7, Logiques de l'éthique (Juin 1993), pp. 149-168.

Purpose This study aims to explore the main concerns and attitudes Basque adolescents have regarding online privacy. It analyzes their motivations for sharing private information and the kind of information they share. Likewise, it examines whether they consider the potential consequences of revealing certain information online and analyzes if there are any differences between the motivations and attitudes of young people from Gipuzkoa and Labourd. Design/methodology/approach For this study, three methods were combined to collect the data in 17 schools in (...) the Basque provinces of Gipuzkoa and Labourd: a survey carried out among 1,133 students, out of which 242 also completed a diary and 482 took part in discussion groups. Findings The data from this research does not fully support the “youth cultures of disclosure” in the Basque Country; however, some of these practices have been observed. Originality/value Time spent online by adolescents has increased sharply in recent years. This increase has brought with it concerns about youth’s level of awareness regarding online privacy. This is the first cross-border study conducted in the Basque Country addressing this topic. (shrink)

Este artículo se ocupa de las relaciones entre poder y verdad en los cursos de Michel Foucault. Busca mostrar cómo se ha pasado de una concepción en la que se insistía en las instancias de poder como productoras de discursos verdad al análisis de la fuerza de la propia verdad como límite del poder. En este contexto, luego de haberse ocupado de la introducción de la idea de voluntad en la arqueología de saber y sus consecuencias, aborda las nociones de (...) régimen de verdad y veridicción. (shrink)

Because of the failed coupe d’etat in Venezuela on April 11th of this year, the country has fallen into an institutional and governability crisis which appears to have no short run solution. This has not only influenced the political activism of new social actors and movements, very distinct f..

The genesis of Feynman's original approach to QED is reviewed. The main ideas of his original presentation at the Pocono Conference are discussed and compared with the ones involved in his action-at-distance formulation of classical electrodynamics. The role of the de Sitter group in Feynman's visualization of space-time processes is emphasized.

Este artículo se ocupa de la recepción de la noción foucaultiana de “gubernamentalidad” en el pensamiento de Roberto Esposito a partir de la traducción al italiano de las lecciones de Foucault de los años 1977 y 1978 en el Collège de France. En primer lugar, se exponen los diferentes contextos de recepción de estas lecciones, en particular en el ámbito anglosajón de los estudios sobre la gubernamentalidad y en el de la crisis del marxismo italiano de finales de los setenta. (...) En segundo lugar, se analiza la posición de Foucault en sus cursos de estos años desde la perspectiva de la oposición entre maquiavelismo y antimaquiavelismo en vista, precisamente, de la recepción italiana. Por último, se aborda la recepción de la noción de “gubernamentalidad” por parte de Roberto Esposito en su obra de 1980, La politica e la storia. El artículo muestra la importancia de esta recepción temprana de las lecciones de Foucault respecto de la formación de la corriente biopolítica italiana y, sobre todo, sus especificidades. (shrink)

This article describes the evolution of the theme of the subject in the work of Michel Foucault. More precisely, it develops the relationship between subject and history, from his first works, dedicated to the history of psychology and of madness, to his courses devoted to biopolitics.Este artículo describe la evolución del tema del sujeto en la obra de Michel Foucault. Más precisamente, desarrolla la relación entre sujeto e historia desde sus primeros trabajos, dedicados a la historia de la psicología y (...) de la locura, hasta sus cursos consagrados a la biopolítica. (shrink)

The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for 60 years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal circumstances, induce an immune reaction. In this paper we show that the self/non-self model is no longer an appropriate explanation of experimental data in immunology, and that this inadequacy may be rooted in an excessively strong metaphysical conception of biological identity. We suggest that (...) another hypothesis, one based on the notion of continuity, gives a better account of immune phenomena. Finally, we underscore the mapping between this metaphysical deflation from self to continuity in immunology and the philosophical debate between substantialism and empiricism about identity. (shrink)

El estudio busca señalar cómo, en la situación espiritual de nuestro presente, arte y filosofía se acercan con frecuencia de tal manera que parece imposible delimitar con precisión uno de otro dominio. Dicha situación es particularmente crítica por cuanto, en nuestro presente, la filosofía mengua a ojos vista en tanto el arte se encuentra también vulnerado en su centro significante. El presente ensayo busca la vía de acceso a las patologías del arte y de la filosofía, que las acercan a (...) transformaciones esenciales. Dichas vías de acceso son fenómenos marginales respecto del núcleo sancionado de la conciencia estética: ocasionalidad, apertura e in-significancia (Guerrero y el autor de este trabajo. Así diseccionado el problema de los modos de interpenetración de arte y filosofía, se muestra que aquí es esencialmente conciencia interna de ésta. (shrink)

El autor intenta fijar los diversos niveles de significado del concepto de "alienación" para determinar, finalmente, su especificidad filosófica. Con tal propósito se recorren los momentos de formación de dicho concepto filosófico que alcanza en Marx un papel clave en la comprensión de la especie humana. Se analiza igualmente,la rehabilitación del término alienación en las ciencias del hombre, y se concluye postulando una teoría fllosófica de la alienación sobre la base del tiempo como su horizonte trascendental-ontológico.